Hydrochloric Acid → HCID 136354630, compound

HRID 1288435Notes

Reaction equation

HRID 1288435 reaction equation
Cl.[N+:2]([C:5]1[C:6]([CH2:19][O:20][CH3:21])=[C:7]2[C:12](=[CH:13][CH:14]=1)[N:11]=[C:10]1[NH:15][C:16](=[O:18])[CH2:17][N:9]1[CH2:8]2)([O-])=O.Cl.[H][H]>C(O)C.[Pd]>[NH2:2][C:5]1[C:6]([CH2:19][O:20][CH3:21])=[C:7]2[C:12](=[CH:13][CH:14]=1)[N:11]=[C:10]1[NH:15][C:16](=[O:18])[CH2:17][N:9]1[CH2:8]2

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 135556899HCID 135556899, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 136354630HCID 136354630, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a suspension of 9.18 g. (3.4 × 10-2 mole) of 7-Nitro-6-methoxymethyl-1,2,3,5-tetrahydroimidazo[2,1-b]-quinazolin-2-one hydrochloride in 95% ethanol (300 ml.) is added 10 ml. of concentrated hydrochloric acid and 0.45 g. of 10% Pd/C catalyst. The mixture is placed on a Paar hydrogenator, shaken until theoretical hydrogen is absorbed, removed and water (150 ml.) added to effect dissolution of the precipitate. The mixture is filtered under suction, the catalyst washed with 95% ethanol and the mixture evaporated to dryness yielding the title product as a yellow powder.

Workup

  1. additionTo a suspension of 9.18 g
  2. customis absorbed
  3. customremoved
  4. additionwater (150 ml.) added
  5. dissolutiondissolution of the precipitate
  6. filtrationThe mixture is filtered under suction
  7. washthe catalyst washed with 95% ethanol
  8. customthe mixture evaporated to dryness

Sources & evidence

ORD record
ord-a96a955c0fc74fbe944e9f2827e1b827
Source dataset
uspto-grants-1976_10
Patent number
US03988340

Reaction notes

Loading…