Methylamine → HCID 21393875, compound

HRID 1288474Notes

Reaction equation

HRID 1288474 reaction equation
[NH2:1][C:2]1C=CC=C2C=1CNCC2.C([N:15]1[CH2:24][CH2:23][C:22]2[C:17](=[C:18]([S:25](Cl)(=[O:27])=[O:26])[CH:19]=[CH:20][CH:21]=2)[CH2:16]1)(=O)C.CN>>[CH3:2][NH:1][S:25]([C:18]1[CH:19]=[CH:20][CH:21]=[C:22]2[C:17]=1[CH2:16][NH:15][CH2:24][CH2:23]2)(=[O:27])=[O:26]

Participants

4

Reactant 3

HCID 6329MethylamineHCID 15896351HCID 15896351, compoundHCID 205232091,2,3,4-Tetrahydroisoquinolin-8-amine

Product 1

HCID 21393875HCID 21393875, compound

Procedure

By the procedure of Example 15, 8-amino-1,2,3,4-tetrahydroisoquinoline is converted to 2-acetyl-8-chlorosulfonyl-1,2,3,4-tetrahydroisoquinoline. Reacting with methylamine by the procedure of Example 27 and hydrolyzing to remove the 2-acetyl group gives 8-methylsulfamoyl-1,2,3,4-tetrahydroisoquinoline.

Workup

  1. customhydrolyzing to remove the 2-acetyl group

Sources & evidence

ORD record
ord-c0070aafdfae48f690613df069eb37d2
Source dataset
uspto-grants-1976_10
Patent number
US03988339

Reaction notes

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