1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 18924588, compound

HRID 1288666Notes

Reaction equation

HRID 1288666 reaction equation
[CH:1]([NH:3][C:4]1[CH:5]=[CH:6][C:7]([C:14]([O:16][CH2:17]C)=[O:15])=[C:8]([S:10]([NH2:13])(=[O:12])=[O:11])[CH:9]=1)=[O:2].[CH3:19][O:20][C:21]1[CH:26]=[C:25]([O:27][CH3:28])[N:24]=[C:23]([NH:29][C:30](OC2C=CC=CC=2)=[O:31])[N:22]=1.C1CCN2C(=NCCC2)CC1>C(#N)C>[CH3:28][O:27][C:25]1[CH:26]=[C:21]([O:20][CH3:19])[N:22]=[C:23]([NH:29][C:30]([NH:13][S:10]([C:8]2[CH:9]=[C:4]([NH:3][CH:1]=[O:2])[CH:5]=[CH:6][C:7]=2[C:14]([O:16][CH3:17])=[O:15])(=[O:11])=[O:12])=[O:31])[N:24]=1

Participants

5

Reactant 3

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 10945667Carbamic acid, N-(4,6-dimethoxy-2-pyrimidinyl)-, phenyl esterHCID 18924592HCID 18924592, compound

Product 1

HCID 18924588HCID 18924588, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

1.00 g of 5-formylamino-2-ethoxycarbonylbenzenesulfonamide, 1.11 g of 4,6-dimethoxy-2-phenoxycarbonylaminopyrimidine and 0.82 ml of DBU in acetonitrile are reacted analogously to Chemical Example A.1; Yield: 1.00 g, M.p.: 113° to 118° C. (dec.), Mass spectrum (CI):(M+l) =454

Sources & evidence

ORD record
ord-a27af7c6d8f3473b8d967435af054178
Source dataset
uspto-grants-1998_05
Patent number
US05747421

Reaction notes

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