Sodium Hydroxide → 2-(Propylthio)-4,6(1H,5H)-pyrimidinedione

HRID 1288853Notes

Reaction equation

HRID 1288853 reaction equation
[CH2:1](I)[CH2:2][CH3:3].[OH:5][C:6]1[CH:11]=[C:10]([OH:12])[N:9]=[C:8]([SH:13])[N:7]=1.[OH-].[Na+]>O>[CH2:1]([S:13][C:8]1[NH:9][C:10](=[O:12])[CH2:11][C:6](=[O:5])[N:7]=1)[CH2:2][CH3:3]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 336431-IodopropaneHCID 178516656HCID 178516656, compound

Product 1

HCID 189249562-(Propylthio)-4,6(1H,5H)-pyrimidinedione

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Propyl iodide (136 ml) was added to a suspension of 4,6-dihydroxy-2-mercaptopyrimidine (200 g) in water (800 ml), containing sodium hydroxide (55.6 g). The reaction mixture was stirred for 2 weeks then concentrated to half volume, 2N hydrochloric acid added and the product isolated by filtration (167 g).

Workup

  1. concentrationthen concentrated to half volume, 2N hydrochloric acid
  2. additionadded
  3. customthe product isolated by filtration (167 g)

Sources & evidence

ORD record
ord-c6629d41b7c348379951ac86c32f2734
Source dataset
uspto-grants-1998_05
Patent number
US05747496

Reaction notes

Loading…