4-Chloro-6,7-dimethoxyquinazoline → HCID 18924998, compound

HRID 1288856Notes

Reaction equation

HRID 1288856 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][N:3]=1.Cl.[N:17]([C:20]1[CH:26]=[CH:25][C:23]([NH2:24])=[CH:22][CH:21]=1)=[N+:18]=[N-:19]>C(O)(C)C>[ClH:1].[N:17]([C:20]1[CH:26]=[CH:25][C:23]([NH:24][C:2]2[C:11]3[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=3)[N:5]=[CH:4][N:3]=2)=[CH:22][CH:21]=1)=[N+:18]=[N-:19]

Participants

4

Reactant 2

HCID 27693644-Chloro-6,7-dimethoxyquinazolineHCID 162112104-Azidoaniline hydrochloride

Product 1

HCID 18924998HCID 18924998, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

4-Chloro-6,7-dimethoxyquinazoline (250 mg, 1.12 mmol) and 4-azidoaniline hydrochloride (200 mg, 1.11 mmol) were refluxed in 10 mL of isopropyl alcohol for 0.5 hour, cooled and filtered to afford solid title product which was washed with 10 mL of isopropyl alcohol and dried in vacuo, at 70° C., 392 mg (98%); mp 200°-205° C. (dec).

Workup

  1. temperaturecooled
  2. filtrationfiltered

Sources & evidence

ORD record
ord-7162b8a304cf4b7b9327ffdad566b892
Source dataset
uspto-grants-1998_05
Patent number
US05747498

Reaction notes

Loading…