反应详情

To 6,7-bis(2-methoxy-ethoxy)-quinazolone (500 mg, 1.7 mmol), from Preparation 1, in CHCl3 (10 mL) containing one drop of DMF was added oxalylchloride (490 μL, 5.6 mmol) in several portions over 5 minutes. Once foaming ceased the solution was refluxed 1.5 hours. The solvent was removed in vacuo and the residue was dissolved in 1,2-dichloroethane (20 mL) and washed two times with 80 mL saturated aqueous Na2CO3. The organic phase was dried over Na2SO4, and concentrated in vacuo to afford solid title product (520 mg, 92%; M.P. 108°-109° C.).

1. temperaturewas refluxed 1.5 hours
2. customThe solvent was removed in vacuo
3. dissolutionthe residue was dissolved in 1,2-dichloroethane (20 mL)
4. washwashed two times with 80 mL saturated aqueous Na2CO3
5. dry with materialThe organic phase was dried over Na2SO4
6. concentrationconcentrated in vacuo