2-Tolyl isocyanate → HCID 86751574, compound

HRID 1288985Notes

Reaction equation

HRID 1288985 reaction equation
[Cl:1][C:2]1[CH:25]=[CH:24][C:5]2[N:6]([C:15](=[O:23])[C:16]3[CH:21]=[CH:20][C:19]([NH2:22])=[CH:18][CH:17]=3)[CH2:7][C:8]3[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=3[CH2:10][C:4]=2[CH:3]=1.[C:26]1([CH3:35])[C:27]([N:32]=[C:33]=[O:34])=[CH:28][CH:29]=[CH:30][CH:31]=1>O1CCCC1>[Cl:1][C:2]1[CH:25]=[CH:24][C:5]2[N:6]([C:15](=[O:23])[C:16]3[CH:21]=[CH:20][C:19]([NH:22][C:33]([NH:32][C:27]4[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=4[CH3:35])=[O:34])=[CH:18][CH:17]=3)[CH2:7][C:8]3[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=3[CH2:10][C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 691942-Tolyl isocyanateHCID 544045372-Chloro-5-(4-aminobenzoyl)-6,11-dihydro-5H-dibenz[b,e]azepine

Product 1

HCID 86751574HCID 86751574, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

As described for Example 122, a mixture of 0.348 g of 2-chloro-5-(4-aminobenzoyl)-6,11-dihydro-5H-dibenz[b,e]azepine and 0.175 g of o-tolylisocyanate in 15 ml of tetrahydrofuran is refluxed overnight and worked-up to give the product as a solid.

Workup

  1. temperatureis refluxed overnight

Sources & evidence

ORD record
ord-022ef5f5b50247609b88d5d0fa3eaad8
Source dataset
uspto-grants-1998_05
Patent number
US05747487

Reaction notes

Loading…