p-Toluenesulfonic acid → HCID 18925306, compound

HRID 1289024Notes

Reaction equation

HRID 1289024 reaction equation
C([O:4][C:5]1[C:6]([O:33]C(C)C)=[CH:7][C:8]2[C:21]3[C:12](=[C:13]4[C:18](=[CH:19][N:20]=3)[C:17]([O:22]CC3C=CC=CC=3)=[C:16]([O:30][CH3:31])[CH:15]=[CH:14]4)[CH:11]=[CH:10][C:9]=2[CH:32]=1)(C)C.[C:37]1([CH3:48])[CH:42]=[CH:41][C:40]([S:43]([O:46]C)(=[O:45])=[O:44])=[CH:39][CH:38]=1.[C:49]1(C)C=CC(S(O)(=O)=O)=CC=1>CO>[S:43]([C:40]1[CH:41]=[CH:42][C:37]([CH3:48])=[CH:38][CH:39]=1)([O-:46])(=[O:45])=[O:44].[OH:4][C:5]1[C:6]([OH:33])=[CH:7][C:8]2[C:21]3[C:12](=[C:13]4[C:18](=[CH:19][N+:20]=3[CH3:49])[C:17]([OH:22])=[C:16]([O:30][CH3:31])[CH:15]=[CH:14]4)[CH:11]=[CH:10][C:9]=2[CH:32]=1

Participants

5

Reactant 3

HCID 6101p-Toluenesulfonic acidHCID 6645Methyl p-toluenesulfonateHCID 18925304HCID 18925304, compound

Product 1

HCID 18925306HCID 18925306, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2,3-diisopropoxy-7-benzyloxy-8-methoxybenzo[c]phenanthridine (compound D-6) and methyl p-toluenesulfonate were subjected to a reaction operation in a manner similar to Example 16 to produce compound E-6, which was further treated with p-toluenesulfonic acid in the presence of methanol, so that compound A-6, wherein X- =OTs-, was obtained.

Workup

  1. customto produce compound E-6, which
  2. customwas obtained

Sources & evidence

ORD record
ord-b31a091b63fd46248b50d592f3eac4a5
Source dataset
uspto-grants-1998_05
Patent number
US05747502

Reaction notes

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