Benzaldehyde → 1-(Benzo[b]furan-2-yl)-3-phenylprop-2-ene-1-one

HRID 1289028Notes

Reaction equation

HRID 1289028 reaction equation
[C:1]([C:4]1[O:8][C:7]2[CH:9]=[CH:10][CH:11]=[CH:12][C:6]=2[CH:5]=1)(=[O:3])[CH3:2].[CH:13](=O)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.Cl>CO>[O:8]1[C:4]([C:1](=[O:3])[CH:2]=[CH:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:5][C:6]2[CH:12]=[CH:11][CH:10]=[CH:9][C:7]1=2

Participants

5

Reactant 3

HCID 240BenzaldehydeHCID 313Hydrochloric AcidHCID 154352-Acetylbenzofuran

Product 1

HCID 6190291-(Benzo[b]furan-2-yl)-3-phenylprop-2-ene-1-one

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

8 g of 2-acetyl benzo[b]furan and 6 g of benzaldehyde are heated to boiling in 50 ml of methanol in the presence of 3 of concentrated hydrochloric acid. The batch is cooled after 10 h, and the precipitated yellow mass of crystals is filtered off by suction and rewashed with a small quantity of cold methanol.

Workup

  1. temperatureThe batch is cooled after 10 h
  2. filtrationthe precipitated yellow mass of crystals is filtered off by suction

Sources & evidence

ORD record
ord-e8696075d85f4e2380722959eae7fb9c
Source dataset
uspto-grants-1998_05
Patent number
US05747508

Reaction notes

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