Hydrochloric Acid → HCID 18925364, compound

HRID 1289056Notes

Reaction equation

HRID 1289056 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([C:12]2[S:16][C:15]([CH3:17])=[N:14][C:13]=2[CH3:18])(O)[CH3:10])=[CH:5][CH:4]=1.Cl.C(=O)([O-])O.[Na+]>C(Cl)(Cl)Cl.C(OCC)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([C:12]2[S:16][C:15]([CH3:17])=[N:14][C:13]=2[CH3:18])=[CH2:10])=[CH:5][CH:4]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 54068620HCID 54068620, compound

Product 1

HCID 18925364HCID 18925364, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6212ChloroformSolvent

Procedure

1- (4-Methoxyphenyl) -1- (2, 4-dimethyl-5-thiazolyl) ethanol (3.69g) in chloroform (50ml) was treated with hydrogen chloride in dry diethyl ether (1M, 14.5ml). After 2 hours at room temperature, aqueous sodium hydrogen carbonate was added and the mixture was extracted with chloroform. The material thus obtained was purified by flash chromatography to yield the title compound.

Workup

  1. extractionthe mixture was extracted with chloroform
  2. customThe material thus obtained
  3. customwas purified by flash chromatography

Sources & evidence

ORD record
ord-5bcd0726edbb4193b843a61dcd4888b3
Source dataset
uspto-grants-1998_05
Patent number
US05747515

Reaction notes

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