Hydrochloric Acid → HCID 2739821, compound

HRID 1289134Notes

Reaction equation

HRID 1289134 reaction equation
[CH:1]([C:3]1[S:7][C:6]([C:8]2[S:9][CH:10]=[CH:11][CH:12]=2)=[CH:5][CH:4]=1)=O.[C:13]([CH:15](CC)[C:16]([O-:18])=[O:17])#[N:14].N1CCC[CH2:23][CH2:22]1.Cl>N1C=CC=CC=1>[CH2:22]([O:18][C:16]([C:15]([C:13]#[N:14])=[CH:1][C:3]1[S:7][C:6]([C:8]2[S:9][CH:10]=[CH:11][CH:12]=2)=[CH:5][CH:4]=1)=[O:17])[CH3:23]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 8082PiperidineHCID 364428[2,2'-Bithiophene]-5-carboxaldehydeHCID 18504529HCID 18504529, compound

Product 1

HCID 2739821HCID 2739821, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

3.9 g of 5-formyl-2,2'-bithiophene, 2.4 ml of cyano-ethyl-acetate, 15 ml of pyridine and 2.4 ml of piperidine were heated at 80°-85° C. for 2 hours. After cooling, the mixture was acidified by diluted HCl and then filtered. The orange crude product was recrystallized from ethanol to give a crystal product (5.02 g). The melting point of the product was 131° C. The yield was 86%.

Workup

  1. temperatureAfter cooling
  2. filtrationfiltered
  3. customThe orange crude product was recrystallized from ethanol

Sources & evidence

ORD record
ord-3b846d8a3b4d44f78d3a9378a7c2991a
Source dataset
uspto-grants-1998_05
Patent number
US05747525

Reaction notes

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