Hydrochloric Acid → HCID 54025347, compound

HRID 1289135Notes

Reaction equation

HRID 1289135 reaction equation
[CH:1]([C:3]1[S:7][C:6]([C:8]2[S:9][C:10]([C:13]3[S:14][CH:15]=[CH:16][CH:17]=3)=[CH:11][CH:12]=2)=[CH:5][CH:4]=1)=O.[C:18]([OH:24])(=[O:23])[CH2:19][C:20]([OH:22])=[O:21].N1CCCCC1.Cl>O.N1C=CC=CC=1>[C:20]([C:19]([C:18]([OH:24])=[O:23])=[CH:1][C:3]1[S:7][C:6]([C:8]2[S:9][C:10]([C:13]3[S:14][CH:15]=[CH:16][CH:17]=3)=[CH:11][CH:12]=2)=[CH:5][CH:4]=1)([OH:22])=[O:21]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 867Malonic AcidHCID 8082PiperidineHCID 454742(2,2':5',2''-Terthiophene)-5-carboxaldehyde

Product 1

HCID 54025347HCID 54025347, compoundYield 84%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 1049PyridineSolvent

Procedure

1.30 g of 5-formyl-2,2':5',2"-terthiophene, 1.04 g of malonic acid, 20 ml of pyridine and 0.1 ml of piperidine were heated at 50°-60° C. for 2 hours. 100 ml of water was added after reaction was completed. The mixture was acidified by diluted HCl and the precipitate collected was recrystallized from ethanol to give reddish crystal (1.43 g). The melting point thereof was 202°-203° C. The yield was 84%.

Workup

  1. customafter reaction
  2. customthe precipitate collected
  3. customwas recrystallized from ethanol

Sources & evidence

ORD record
ord-8888160d5a0d4852b9b45115edeefb71
Source dataset
uspto-grants-1998_05
Patent number
US05747525

Reaction notes

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