反应详情

A solution of 1-bromodecane (11.05 g, 0.050 mol) in butanone (50 ml) was added dropwise to a stirred, refluxing mixture of methyl-3-hydroxybenzoate (5.0 g, 0.033 mol) and anhydrous potassium carbonate (K2CO3) (30.0 g, 0.20 mol) in butanone (200 ml). The stirred mixture was heated under reflux for 24 h. The K2CO3 was filtered off and the solvent removed. The residue was purified by gravity column chromatography (silica gel/dichloromethane) to yield a colourless oil.

1. temperaturerefluxing
2. temperatureThe stirred mixture was heated
3. temperatureunder reflux for 24 h
4. filtrationThe K2CO3 was filtered off
5. customthe solvent removed
6. customThe residue was purified by gravity column chromatography (silica gel/dichloromethane)
7. customto yield a colourless oil