HCID 23206543, compound → HCID 23206558, compound

HRID 1289425Notes

Reaction equation

HRID 1289425 reaction equation
[CH2:1]([O:3][P:4]([CH:9]1[CH:18]=[CH:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([C:19]([F:22])([F:21])[F:20])[CH:15]=2)[N:10]1[C:23]([O:25][CH2:26][C:27]([Cl:30])([Cl:29])[Cl:28])=[O:24])(=[O:8])[O:5][CH2:6][CH3:7])[CH3:2]>C(O)C.[Pt](=O)=O>[CH2:6]([O:5][P:4]([CH:9]1[CH2:18][CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([C:19]([F:20])([F:21])[F:22])[CH:15]=2)[N:10]1[C:23]([O:25][CH2:26][C:27]([Cl:30])([Cl:28])[Cl:29])=[O:24])(=[O:8])[O:3][CH2:1][CH3:2])[CH3:7]

Participants

4

Reactant 1

HCID 23206543HCID 23206543, compound

Product 1

HCID 23206558HCID 23206558, compound

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 702EthanolSolvent

Procedure

71.6 g of 1-(2,2,2-trichloroethoxycarbonyl)-6-trifluoromethyl-1,2-dihydroquinoline-2-phosphonic acid diethyl ester is dissolved in 800 ml of ethanol, mixed with 3.6 g of platinum(IV)-oxide and hydrogenated at normal pressure. It is filtered, concentrated by evaporation and recrystallized from isopropyl ether.

Workup

  1. filtrationIt is filtered
  2. concentrationconcentrated by evaporation
  3. customrecrystallized from isopropyl ether

Sources & evidence

ORD record
ord-641795bc3bb9400f89618ea2237aa057
Source dataset
uspto-grants-1998_05
Patent number
US05750526

Reaction notes

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