HCID 23206554, compound → HCID 23206537, compound

HRID 1289432Notes

Reaction equation

HRID 1289432 reaction equation
[CH2:1]([O:3][P:4]([C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([C:19]([F:22])([F:21])[F:20])[CH:17]=2)[N:12]=[CH:11][CH:10]=1)(=[O:8])[O:5][CH2:6][CH3:7])[CH3:2]>C(O)(=O)C.[Pt](=O)=O>[CH2:6]([O:5][P:4]([CH:9]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([C:19]([F:20])([F:21])[F:22])[CH:17]=2)[NH:12][CH2:11][CH2:10]1)(=[O:8])[O:3][CH2:1][CH3:2])[CH3:7]

Participants

4

Reactant 1

HCID 23206554HCID 23206554, compound

Product 1

HCID 23206537HCID 23206537, compoundYield 64.6%

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 176Acetic AcidSolvent

Procedure

8.32 g of 6-trifluoromethyl-quinoline-4-phosphonic acid diethyl ester is dissolved in 100 ml of glacial acetic acid, mixed with 1.0 g of platinum dioxide and hydrogenated at room temperature. After column chromatography, 5.44 g of 6-trifluoromethyl-1,2,3,4-tetrahydroquinoline-4-phosphonic acid diethyl ester of melting point 94° C. is obtained.

Sources & evidence

ORD record
ord-6a368d4d311042b7aa4b3acc1d0fa9ff
Source dataset
uspto-grants-1998_05
Patent number
US05750526

Reaction notes

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