Sodium hydride → HCID 18921576, compound

HRID 1289469Notes

Reaction equation

HRID 1289469 reaction equation
Cl.[CH3:2][N:3]([CH3:7])[CH2:4][CH2:5][SH:6].[H-].[Na+].Br[C:11]1[S:15][C:14]([CH:16]=[O:17])=[CH:13][CH:12]=1>CS(C)=O>[CH3:2][N:3]([CH3:7])[CH2:4][CH2:5][S:6][C:11]1[S:15][C:14]([CH:16]=[O:17])=[CH:13][CH:12]=1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 25798Captamine HydrochlorideHCID 784285-Bromothiophene-2-carbaldehyde

Product 1

HCID 18921576HCID 18921576, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Conditions

Temperature
90 °C

Procedure

2-dimethylaminoethanethiol hydrochloride (1.85 g, 13.09 mmol) was suspended in dry DMSO and sodium hydride (60% dispersed in mineral oil, 1.10 g, 2.1 equivs) was added carefully. The reaction mixture was left stirring for 1 hour before 5-bromo-2-thiophenecarboxaldehyde (2.5 g, 1.56 ml, 13.09 mmol) was added. The reaction mixture was then heated to 90° C. under nitrogen.

Workup

  1. waitThe reaction mixture was left
  2. additionwas added

Sources & evidence

ORD record
ord-fee46f50f23148b78597c57e1613a39e
Source dataset
uspto-grants-1998_05
Patent number
US05750530

Reaction notes

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