4-Fluoro-2-methylaniline → HCID 18921792, compound

HRID 1289499Notes

Reaction equation

HRID 1289499 reaction equation
[CH3:1][C:2]1[CH:8]=[C:7]([F:9])[CH:6]=[CH:5][C:3]=1[NH2:4].[CH3:10][C:11]1[N:16]=[C:15]([Cl:17])[N:14]=[C:13]([N:18]2[CH2:27][CH2:26][C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH:19]2[CH3:28])[CH:12]=1>CN(C)C=O>[ClH:17].[CH3:10][C:11]1[N:16]=[C:15]([NH:4][C:3]2[CH:5]=[CH:6][C:7]([F:9])=[CH:8][C:2]=2[CH3:1])[N:14]=[C:13]([N:18]2[CH2:27][CH2:26][C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH:19]2[CH3:28])[CH:12]=1

Participants

4

Reactant 2

HCID 679824-Fluoro-2-methylanilineHCID 18921781HCID 18921781, compound

Product 1

HCID 18921792HCID 18921792, compoundYield 54.7%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

After 2-methyl-4-fluoroaniline(1.1 ml, 10.2 mmol) was added to a mixture solution of 6-methyl-4-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)-2-chloropyrimidine(1.5 g, 5.5 mmol) and dimethylformamide(10 ml), 1.2 g of the titled compound was obtained in accordance with the same procedure as in Step 2 of Example 1.

Sources & evidence

ORD record
ord-5f9079fdd6cf4684840b2e049cfc93dd
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

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