N-Methylaniline → HCID 69957373, compound

HRID 1289508Notes

Reaction equation

HRID 1289508 reaction equation
[CH3:1][NH:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH3:9][CH:10]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:13][CH2:12][N:11]1[C:20]1[CH:25]=[C:24]([CH2:26][CH2:27][CH3:28])[N:23]=[C:22]([Cl:29])[N:21]=1>CN(C)C=O>[ClH:29].[CH3:1][N:2]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1)[C:22]1[N:21]=[C:20]([N:11]2[CH2:12][CH2:13][C:14]3[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:10]2[CH3:9])[CH:25]=[C:24]([CH2:26][CH2:27][CH3:28])[N:23]=1

Participants

4

Reactant 2

HCID 7515N-MethylanilineHCID 18921736HCID 18921736, compound

Product 1

HCID 69957373HCID 69957373, compoundYield 73.7%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

After N-methylaniline(0.27 ml, 2.49 mmol) was added to a mixture solution of 4-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)-6-propyl-2-chloropyrimidine(0.5 g, 1.66 mmol) and dimethylformamide (5 ml), 0.5 g of the title compound was obtained in accordance with the same procedure as in Step 2 of Example 1.

Sources & evidence

ORD record
ord-671c8ed2d372408c8eb054ae4839bab0
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

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