Dimethylformamide → HCID 18921704, compound

HRID 1289523Notes

Reaction equation

HRID 1289523 reaction equation
[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([CH3:9])[CH:3]=1.[CH3:10][C:11]1[C:12]([N:20]2[CH2:29][CH2:28][C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[CH2:21]2)=[N:13][C:14]([Cl:19])=[N:15][C:16]=1[CH2:17][CH3:18].[CH3:30]N(C)C=O>>[ClH:19].[CH3:10][C:11]1[C:12]([N:20]2[CH2:29][CH2:28][C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[CH:21]2[CH3:30])=[N:13][C:14]([NH:6][C:5]2[CH:7]=[CH:8][C:2]([F:1])=[CH:3][C:4]=2[CH3:9])=[N:15][C:16]=1[CH2:17][CH3:18]

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 679824-Fluoro-2-methylanilineHCID 18921790HCID 18921790, compound

Product 1

HCID 18921704HCID 18921704, compoundYield 22.1%

Procedure

After 4-fluoro-2-methylaniline(0.55 ml, 4.95 mmol) was added to a mixture solution of 5-methyl-6-ethyl-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)-2-chloropyrimidine(0.80 g, 2.65 mmol) and dimethylformamide (5 ml), 0.25 g of the titled compound was obtained in accordance with the same procedure as in Step 2 of Example 1.

Sources & evidence

ORD record
ord-9acd0d6f1f5e45d4bd0bfe1472f1211f
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

Loading…