N-Methylaniline → HCID 69956464, compound

HRID 1289532Notes

Reaction equation

HRID 1289532 reaction equation
[CH3:1][NH:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH3:9][CH:10]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:13][CH2:12][N:11]1[C:20]1[N:25]=[C:24]([Cl:26])[NH:23][C:22]2=[CH:27][CH:28]=[CH:29][C:21]=12>CN(C)C=O>[ClH:26].[CH3:1][N:2]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1)[C:24]1[NH:23][C:22]2=[CH:27][CH:28]=[CH:29][C:21]2=[C:20]([N:11]2[CH2:12][CH2:13][C:14]3[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:10]2[CH3:9])[N:25]=1

Participants

4

Reactant 2

HCID 7515N-MethylanilineHCID 18921721HCID 18921721, compound

Product 1

HCID 69956464HCID 69956464, compoundYield 29.1%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

After N-methylaniline(0.20 ml, 1.90 mmol) was added to a mixture solution of 4-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)-2-chlorocyclopenta[d]pyrimidine (0.51 g, 1.70 mmol) and dimethylformamide(5 ml), 0.20 g of the titled compound was obtained in accordance with the same procedure as in Step 2 of Example 1.

Sources & evidence

ORD record
ord-f4a4cc5c28cf4d28a0f65e1a11d7ad3b
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

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