4-Fluoro-2-methylaniline → HCID 18921728, compound

HRID 1289535Notes

Reaction equation

HRID 1289535 reaction equation
[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([CH3:9])[CH:3]=1.[CH3:10][CH:11]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:14][CH2:13][N:12]1[C:21]1[C:30]2[CH2:29][CH2:28][CH2:27][CH2:26][C:25]=2[N:24]=[C:23]([Cl:31])[N:22]=1>CN(C)C=O>[ClH:31].[CH3:9][C:4]1[CH:3]=[C:2]([F:1])[CH:8]=[CH:7][C:5]=1[NH:6][C:23]1[N:22]=[C:21]([N:12]2[CH2:13][CH2:14][C:15]3[C:20](=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH:11]2[CH3:10])[C:30]2[CH2:29][CH2:28][CH2:27][CH2:26][C:25]=2[N:24]=1

Participants

4

Reactant 2

HCID 679824-Fluoro-2-methylanilineHCID 18921711HCID 18921711, compound

Product 1

HCID 18921728HCID 18921728, compoundYield 55.1%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

After 4-fluoro-2-methylaniline(0.60 ml, 5.4 mmol) was added to a mixture solution of 4-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)-2-chloro-5,6,7,8-tetrahydroquinazoline(0.75 g, 2.40 mmol) and dimethylformamide(5 ml), 0.58 g of the titled compound was obtained in accordance with the same procedure as in Step 2 of Example 1.

Sources & evidence

ORD record
ord-0ea108f06c854a839d92adcc7210c535
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

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