4-Fluoro-2-methylaniline → HCID 18921767, compound

HRID 1289554Notes

Reaction equation

HRID 1289554 reaction equation
[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([CH3:9])[CH:3]=1.[CH2:10]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:13][CH2:12][N:11]1[C:20]1([Cl:29])[N:25]=[CH:24]N=C2C=CC=C12>CN(C)C=O>[ClH:29].[CH3:9][C:4]1[CH:3]=[C:2]([F:1])[CH:8]=[CH:7][C:5]=1[NH:6][C:20]1([N:11]2[CH2:12][CH2:13][C:14]3[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH2:10]2)[N:25]=[C:24]2[CH:8]=[CH:2][CH:3]=[C:4]2[CH:5]=[N:6]1

Participants

4

Reactant 2

HCID 679824-Fluoro-2-methylanilineHCID 86752540HCID 86752540, compound

Product 1

HCID 18921767HCID 18921767, compoundYield 75.6%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

After 4-fluoro-2-methylaniline(0.25 ml, 2.20 mmol) was added to a mixture solution of 4-(1,2,3,4-tetrahydroisoquinolin-2-yl)-4-chlorocyclopenta[d]pyrimidine(0.58 g, 2.0 mmol) and dimethylformamide(5 ml), 0.34 g of the titled compound was obtained in accordance with the same procedure as in Step 2 of Example 1.

Sources & evidence

ORD record
ord-520c004ba9474f7b8435c5a5c63fa2a7
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

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