N-Methylaniline → HCID 69955846, compound

HRID 1289558Notes

Reaction equation

HRID 1289558 reaction equation
[CH3:1][NH:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH2:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH2:12][CH2:11][N:10]1[C:19]1[C:28]2[CH2:27][CH2:26][CH2:25][CH2:24][C:23]=2[N:22]=[C:21]([Cl:29])[N:20]=1>CN(C)C=O>[ClH:29].[CH3:1][N:2]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1)[C:21]1[N:20]=[C:19]([N:10]2[CH2:11][CH2:12][C:13]3[C:18](=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH2:9]2)[C:28]2[CH2:27][CH2:26][CH2:25][CH2:24][C:23]=2[N:22]=1

Participants

4

Reactant 2

HCID 7515N-MethylanilineHCID 18921761HCID 18921761, compound

Product 1

HCID 69955846HCID 69955846, compoundYield 39.3%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

After N-methylaniline(0.70 ml, 6.3 mmol) was added to a mixture solution of 4-(1,2,3,4-tetrahydroisoquinolin-2-yl)-2-chloro-5,6,7,8-tetrahydroquinazoline(0.90 g, 3.0 mmol) and dimethylformamide(5 ml), 0.48 g of the titled compound was obtained in accordance with the same procedure as in Step 2 of Example 1.

Sources & evidence

ORD record
ord-73beb8e491af4fd4ab26e932234f85bb
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

Loading…