4-Fluoro-2-methylaniline → HCID 18921708, compound

HRID 1289561Notes

Reaction equation

HRID 1289561 reaction equation
[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([CH3:9])[CH:3]=1.[CH3:10][C:11]1[N:16]=[C:15]([Cl:17])[N:14]=[C:13]([N:18]2[CH2:23][CH2:22][C:21]3[CH:24]=[CH:25][S:26][C:20]=3[CH:19]2[CH3:27])[CH:12]=1>CN(C)C=O>[ClH:17].[CH3:10][C:11]1[N:16]=[C:15]([NH:6][C:5]2[CH:7]=[CH:8][C:2]([F:1])=[CH:3][C:4]=2[CH3:9])[N:14]=[C:13]([N:18]2[CH2:23][CH2:22][C:21]3[CH:24]=[CH:25][S:26][C:20]=3[CH:19]2[CH3:27])[CH:12]=1

Participants

4

Reactant 2

HCID 679824-Fluoro-2-methylanilineHCID 18921666HCID 18921666, compound

Product 1

HCID 18921708HCID 18921708, compoundYield 44.5%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

After 4-fluoro-2-methylaniline(0.5 ml, 4.6 mmol) was added to a mixture solution of 6-methyl-4-(7-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-6-yl)-2-chloropyrimidine(0.7 g, 2.5 mmol) and dimethylformamide(10 ml), 0.45 g of the titled compound was obtained in accordance with the same procedure as in Step 2 of Example 1.

Sources & evidence

ORD record
ord-af372a933bcc4d7e816edeb8f3112688
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

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