4-Fluoroaniline → HCID 18921700, compound

HRID 1289562Notes

Reaction equation

HRID 1289562 reaction equation
[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[CH3:9][C:10]1[N:15]=[C:14]([Cl:16])[N:13]=[C:12]([N:17]2[CH2:22][CH2:21][C:20]3[CH:23]=[CH:24][S:25][C:19]=3[CH:18]2[CH3:26])[CH:11]=1>CN(C)C=O>[ClH:16].[CH3:9][C:10]1[N:15]=[C:14]([NH:6][C:5]2[CH:7]=[CH:8][C:2]([F:1])=[CH:3][CH:4]=2)[N:13]=[C:12]([N:17]2[CH2:22][CH2:21][C:20]3[CH:23]=[CH:24][S:25][C:19]=3[CH:18]2[CH3:26])[CH:11]=1

Participants

4

Reactant 2

HCID 97314-FluoroanilineHCID 18921666HCID 18921666, compound

Product 1

HCID 18921700HCID 18921700, compoundYield 71.6%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

After 4-fluoroaniline(0.4 ml, 3.7 mmol) was added to a mixture solution of 6-methyl-4-(7-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-6-yl)-2-chloropyrimidine(0.7 g, 2.5 mmol) and dimethylformamide(10 ml), 0.7 g of the titled compound was obtained in accordance with the same procedure as in Step 2 of Example 1.

Sources & evidence

ORD record
ord-f11e03b115024adc9b03aaf460f0bc23
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

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