2,4-Dichloro-5,6-dimethylpyrimidine → HCID 18921690, compound

HRID 1289564Notes

Reaction equation

HRID 1289564 reaction equation
[CH3:1][C:2]1[C:3](Cl)=[N:4][C:5]([Cl:9])=[N:6][C:7]=1[CH3:8].[CH3:11][CH:12]1[C:17]2[S:18][CH:19]=[CH:20][C:16]=2[CH2:15][CH2:14][NH:13]1>CN(C)C=O>[CH3:1][C:2]1[C:3]([N:13]2[CH2:14][CH2:15][C:16]3[CH:20]=[CH:19][S:18][C:17]=3[CH:12]2[CH3:11])=[N:4][C:5]([Cl:9])=[N:6][C:7]=1[CH3:8]

Participants

4

Reactant 2

HCID 2415532,4-Dichloro-5,6-dimethylpyrimidineHCID 145481697-Methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine

Product 1

HCID 18921690HCID 18921690, compoundYield 39.4%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In accordance with the same procedure as in Step 1 of Example 1, except that N,N-dimethylformamide(20 ml), 5,6-dimethyl-2,4-dichloropyrimidine(2.8 g, 16 mmol) prepared in Step 1 of Example 12 and 7-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine (2.7 g, 17.6 mmol) in Preparation 2 were used as starting materials, 1.85 g of the titled compound was prepared. (Yield: 39.4%)

Sources & evidence

ORD record
ord-6401f60c38ed4791ad2735fa0f848147
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

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