4-Fluoro-2-methylaniline → HCID 18921669, compound

HRID 1289565Notes

Reaction equation

HRID 1289565 reaction equation
[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([CH3:9])[CH:3]=1.[CH3:10][C:11]1[C:12]([N:19]2[CH2:24][CH2:23][C:22]3[CH:25]=[CH:26][S:27][C:21]=3[CH:20]2[CH3:28])=[N:13][C:14]([Cl:18])=[N:15][C:16]=1[CH3:17]>CN(C)C=O>[ClH:18].[CH3:10][C:11]1[C:12]([N:19]2[CH2:24][CH2:23][C:22]3[CH:25]=[CH:26][S:27][C:21]=3[CH:20]2[CH3:28])=[N:13][C:14]([NH:6][C:5]2[CH:7]=[CH:8][C:2]([F:1])=[CH:3][C:4]=2[CH3:9])=[N:15][C:16]=1[CH3:17]

Participants

4

Reactant 2

HCID 679824-Fluoro-2-methylanilineHCID 18921690HCID 18921690, compound

Product 1

HCID 18921669HCID 18921669, compoundYield 12.5%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

After 4-fluoro-2-methylaniline(0.5 ml, 4.6 mmol) was added to a mixture solution of 5,6-dimethyl-4-(7-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-6-yl)-2-chloropyrimidine(0.68 g, 2.3 mmol) and dimethylformamide(5 ml), 0.12 g of the titled compound was obtained in accordance with the same procedure as in Step 2 of Example 1.

Sources & evidence

ORD record
ord-f09d391f38a741a3aeb33cef8b607805
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

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