4-Fluoroaniline → HCID 18921763, compound

HRID 1289579Notes

Reaction equation

HRID 1289579 reaction equation
[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[CH2:9]([C:11]1[N:16]=[C:15]([N:17]2[CH2:26][CH2:25][C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH2:18]2)[N:14]=[C:13]([Cl:27])[CH:12]=1)[CH3:10]>CN(C)C=O>[ClH:27].[CH2:9]([C:11]1[N:16]=[C:15]([N:17]2[CH2:26][CH2:25][C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH2:18]2)[N:14]=[C:13]([NH:6][C:5]2[CH:7]=[CH:8][C:2]([F:1])=[CH:3][CH:4]=2)[CH:12]=1)[CH3:10]

Participants

4

Reactant 2

HCID 97314-FluoroanilineHCID 18921804HCID 18921804, compound

Product 1

HCID 18921763HCID 18921763, compoundYield 78.3%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

After 4-fluoroaniline(0.30 ml, 3.17 mmol) was added to a mixture solution of 6-ethyl-2-(1,2,3,4-tetrahydroisoquinolin-2-yl)-4-chloropyrimidine(0.40 g, 1.46 mmol) and dimethylformamide(10 ml), 0.44 g of the titled compound was obtained in accordance with the same procedure as in Step 4 of Example 57.

Sources & evidence

ORD record
ord-db15717570b34134b53e3fd24a8ea015
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

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