4-Fluoro-2-methylaniline → HCID 18921730, compound

HRID 1289596Notes

Reaction equation

HRID 1289596 reaction equation
[CH3:1][C:2]1[CH:8]=[C:7]([F:9])[CH:6]=[CH:5][C:3]=1[NH2:4].[CH3:10][C:11]1[C:12]([Cl:30])=[N:13][C:14]([N:19]2[CH2:28][CH2:27][C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[CH:20]2[CH3:29])=[N:15][C:16]=1[CH2:17][CH3:18]>CN(C)C=O>[ClH:30].[CH3:10][C:11]1[C:12]([NH:4][C:3]2[CH:5]=[CH:6][C:7]([F:9])=[CH:8][C:2]=2[CH3:1])=[N:13][C:14]([N:19]2[CH2:28][CH2:27][C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[CH:20]2[CH3:29])=[N:15][C:16]=1[CH2:17][CH3:18]

Participants

4

Reactant 2

HCID 679824-Fluoro-2-methylanilineHCID 18921756HCID 18921756, compound

Product 1

HCID 18921730HCID 18921730, compoundYield 41%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

After 2-methyl-4-fluoroaniline(0.42 ml, 3.8 mmol) was added to a mixture solution of 5-methyl-6-ethyl-2-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)-4-chloropyrimidine(0.6 g, 2.0 mmol) and dimethylformamide(10 ml), 0.35 g of the titled compound was obtained in accordance with the same procedure as in Step 4 of Example 57.

Sources & evidence

ORD record
ord-f51ba1340eca43aea6e2dafc6e2c1e71
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

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