4-Fluoro-2-methylaniline → HCID 18921667, compound

HRID 1289597Notes

Reaction equation

HRID 1289597 reaction equation
[CH3:1][C:2]1[CH:8]=[C:7]([F:9])[CH:6]=[CH:5][C:3]=1[NH2:4].[CH3:10][CH:11]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:14][CH2:13][N:12]1[C:21]1[NH:26][C:25]2=[CH:27][CH:28]=[CH:29][C:24]2=[C:23]([Cl:30])[N:22]=1>CN(C)C=O>[ClH:30].[CH3:1][C:2]1[CH:8]=[C:7]([F:9])[CH:6]=[CH:5][C:3]=1[NH:4][C:23]1[N:22]=[C:21]([N:12]2[CH2:13][CH2:14][C:15]3[C:20](=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH:11]2[CH3:10])[NH:26][C:25]2=[CH:27][CH:28]=[CH:29][C:24]=12

Participants

4

Reactant 2

HCID 679824-Fluoro-2-methylanilineHCID 178421594HCID 178421594, compound

Product 1

HCID 18921667HCID 18921667, compoundYield 12%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

After 2-methyl-4-fluoroaniline(0.46 ml, 4.2 mmol) was added to a mixture solution of 2-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)-4-chlorocyclopenta[d]pyrimidine(0.6 g, 2.0 mmol) and dimethylformamide(10 ml), 0.10 g of the titled compound was obtained in accordance with the same procedure as in Step 4 of Example 57.

Sources & evidence

ORD record
ord-ad9a382c1fc94a9e83a6173e3c3544ec
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

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