Sodium → 3-Amino-5-(4-chloro-1-naphthyl)-1H-1,2,4-triazol

HRID 1289771Notes

Reaction equation

HRID 1289771 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([C:12](OC)=O)=[CH:4][CH:3]=1.[Na].[N+]([O-])(O)=O.[NH2:21][NH:22][C:23]([NH2:25])=[NH:24]>CO>[NH2:25][C:23]1[N:24]=[C:12]([C:5]2[C:6]3[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=3)[C:2]([Cl:1])=[CH:3][CH:4]=2)[NH:21][N:22]=1

Participants

5

Reactant 3

HCID 5360545SodiumHCID 222616151-Naphthalenecarboxylic acid, 4-chloro-, methyl esterHCID 178513186HCID 178513186, compound

Product 1

HCID 107528543-Amino-5-(4-chloro-1-naphthyl)-1H-1,2,4-triazol

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The synthesis method of Example 7-(2) was applied. The compound (1.90 g) obtained in (3) above, methanol (20 ml), metallic sodium (810 mg) and aminoguanidine nitrate (4.8 g) were used as reagents to give a brown solid (2.27 g). The obtained compound was used as it was in the next reaction.

Sources & evidence

ORD record
ord-8a69dfb4bb214ae4bba3778604442fac
Source dataset
uspto-grants-1998_05
Patent number
US05750545

Reaction notes

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