反应详情

The synthesis method of Example 7-(3) was applied. The compound (4.00 g) obtained in (2) above, 0.67N sodium hydroxide (30 ml), methyl isothiocyanate (1.52 g) and tetrahydrofuran (30 ml) were used as reagents and the mixture was reacted at room temperature for 4 hours. After the reaction, the mixture was neutralized with 2N hydrochloric acid. The resulting substance was collected by filtration and washed with water and hexane-ethyl acetate to give 3.67 g of white crystals (yield 69%).

1. customthe mixture was reacted at room temperature for 4 hours
2. customAfter the reaction
3. filtrationThe resulting substance was collected by filtration
4. washwashed with water and hexane-ethyl acetate