Hydrochloric Acid → HCID 85265460, compound

HRID 1289788Notes

Reaction equation

HRID 1289788 reaction equation
[NH2:1][C:2]1[N:6]=[C:5]([CH:7]=[CH:8][C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)[NH:4][N:3]=1.[OH-].[Na+].[CH3:18][N:19]=[C:20]=[S:21].Cl>O1CCCC1>[NH2:1][C:2]1[N:3]([C:20]([NH:19][CH3:18])=[S:21])[N:4]=[C:5]([CH:7]=[CH:8][C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)[N:6]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 11167Methyl isothiocyanateHCID 14798Sodium HydroxideHCID 54445936HCID 54445936, compound

Product 1

HCID 85265460HCID 85265460, compoundYield 69%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The synthesis method of Example 7-(3) was applied. The compound (4.00 g) obtained in (2) above, 0.67N sodium hydroxide (30 ml), methyl isothiocyanate (1.52 g) and tetrahydrofuran (30 ml) were used as reagents and the mixture was reacted at room temperature for 4 hours. After the reaction, the mixture was neutralized with 2N hydrochloric acid. The resulting substance was collected by filtration and washed with water and hexane-ethyl acetate to give 3.67 g of white crystals (yield 69%).

Workup

  1. customthe mixture was reacted at room temperature for 4 hours
  2. customAfter the reaction
  3. filtrationThe resulting substance was collected by filtration
  4. washwashed with water and hexane-ethyl acetate

Sources & evidence

ORD record
ord-86eecdfd51cb48a192ba44bb64a3e5a6
Source dataset
uspto-grants-1998_05
Patent number
US05750545

Reaction notes

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