Phenylpropynoic acid methyl ester → HCID 10655081, compound

HRID 1289790Notes

Reaction equation

HRID 1289790 reaction equation
[C:1]1([C:7]#[C:8][C:9](OC)=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Na].[C:14]([NH:17][NH2:18])([NH2:16])=[NH:15].Cl>CO>[NH2:16][C:14]1[N:15]=[C:9]([C:8]#[C:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[NH:18][N:17]=1

Participants

5

Reactant 3

HCID 138378Phenylpropynoic acid methyl esterHCID 5360545SodiumHCID 178418668HCID 178418668, compound

Product 1

HCID 10655081HCID 10655081, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The synthesis method of Example 7-(2) was applied. The compound (5.63 g) obtained in (1) above, methanol (85 ml), metallic sodium (3.29 g) and aminoguanidine hydrochloride (15.8 g) were used as reagents to give 4.87 g of a pale-brown solid (yield 75%).

Sources & evidence

ORD record
ord-c3b85abe699c4f6abb8e7fecf294166a
Source dataset
uspto-grants-1998_05
Patent number
US05750545

Reaction notes

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