Dimethylformamide → HCID 10513597, compound

HRID 1289794Notes

Reaction equation

HRID 1289794 reaction equation
[NH2:1][C:2]1[N:6]=[CH:5][NH:4][N:3]=1.CN(C)C=O.[OH:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][N:18]=[C:19]=[S:20]>C(Cl)(Cl)Cl.CO>[NH2:1][C:2]1[N:3]([C:19]([NH:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][OH:12])=[S:20])[N:4]=[CH:5][N:6]=1

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 104869815-Hydroxypentyl isothiocyanateHCID 178418311HCID 178418311, compound

Product 1

HCID 10513597HCID 10513597, compoundYield 19%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

The synthesis method of Example 1-(3) was applied. 3-Amino-1H-1,2,4-triazole (4.00 g), dimethylformamide (25 ml) and 5-hydroxypentyl isothiocyanate (9.24 g) were used as reagents. After the reaction, silica gel column chromatography (chloroform-methanol) was applied to give 2.06 g of white crystals (yield 19%). The crystals were subjected to recrystallization from chloroform to give white crystals.

Sources & evidence

ORD record
ord-a324b6d0dd5c453fb78dcb3aa5713fed
Source dataset
uspto-grants-1998_05
Patent number
US05750545

Reaction notes

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