HCID 11132869, compound → HCID 11025076, compound

HRID 1289804Notes

Reaction equation

HRID 1289804 reaction equation
C(O[C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15](=[O:28])[C:16]([CH:24]2[CH2:27][CH2:26][CH2:25]2)([OH:23])[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:10][CH2:9]1)=O)(C)(C)C>Cl.O1CCOCC1>[CH3:15][C:16]([CH3:24])=[CH:17][CH2:18][CH2:6][N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15](=[O:28])[C:16]([CH:24]2[CH2:25][CH2:26][CH2:27]2)([OH:23])[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH2:10][CH2:9]1

Participants

4

Reactant 1

HCID 11132869HCID 11132869, compound

Product 1

HCID 11025076HCID 11025076, compoundYield 174.1%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

1.0 g of N-(1-t-butoxycarbonylpiperidin-4-yl)-2-cyclobutyl-2-hydroxy-2-phenylacetamide was dissolved in 25 ml of a 4N hydrochloric acid solution in dioxane, and this solution was stirred at room temperature overnight. Then, the reaction mixture was evaporated to dryness under reduced pressure to obtain 0.83 g of the title compound.

Workup

  1. customThen, the reaction mixture was evaporated to dryness under reduced pressure

Sources & evidence

ORD record
ord-7f263680a5fb4d00a3e1cd1391766b89
Source dataset
uspto-grants-1998_05
Patent number
US05750540

Reaction notes

Loading…