Hydrochloric Acid → [1-(4-Methyl-3-pentenyl)piperidin-4-yl] 2-cyclobutyl-2-hydroxy-2-phenylacetate

HRID 1289806Notes

Reaction equation

HRID 1289806 reaction equation
Cl.C(O[C:7]([N:9]1[CH2:14][CH2:13][CH:12]([O:15][C:16](=[O:29])[C:17]([CH:25]2[CH2:28][CH2:27][CH2:26]2)([OH:24])[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH2:11][CH2:10]1)=O)(C)(C)C>CO>[CH:25]1([C:17]([OH:24])([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:16]([O:15][CH:12]2[CH2:13][CH2:14][N:9]([CH2:7][CH2:19][CH:18]=[C:17]([CH3:25])[CH3:16])[CH2:10][CH2:11]2)=[O:29])[CH2:28][CH2:27][CH2:26]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18922030HCID 18922030, compound

Product 1

HCID 18922143[1-(4-Methyl-3-pentenyl)piperidin-4-yl] 2-cyclobutyl-2-hydroxy-2-phenylacetateYield 175.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A 10% methanolic solution of hydrochloric acid was added to a solution of 2.68 g of (1-t-butoxycarbonylpiperidin-4-yl)-2-cyclobutyl-2-hydroxy-2-phenylacetate in 50 ml of methanol, and this mixture was stirred at room temperature for 10 hours. The solvent was distilled off under reduced pressure to obtain 2.24 g of the title compound.

Workup

  1. distillationThe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-a73f01c8a4f14a2b93e63f0157d2cb86
Source dataset
uspto-grants-1998_05
Patent number
US05750540

Reaction notes

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