反应详情

To a solution of 25 mg of amine prepared in Example 11 and 0.05 mL of DIPEA in 0.5 mL of methylene chloride was added 15 mg of dimethylcarbamoyl chloride. After 2 h at 50° C. in a sealed vial, the volatiles were evaporated under a stream of nitrogen and the residue was purified on a 1 mm preparative silica gel plate eluted with ethyl acetate to afford 25 mg of title compound. Mass spec (NH3 /CI): 489 (M+1).

1. customAfter 2 h at 50° C. in a sealed vial, the volatiles were evaporated under a stream of nitrogen
2. customthe residue was purified on a 1 mm preparative silica gel plate
3. washeluted with ethyl acetate