反应详情

Oxalyl chloride (18.1 ml, 36.1 mmol, 1.25 eq., 2M in CH2Cl2) was added to a solution of 2-nitro-3-methyl-benzoic acid (5.237 g, 28.9 mmol, 1.0 eq.) in CH2Cl2 (57.8 ml, 0.5M) and dimethylformamide (0.14 ml, 0.25% of CH2Cl2) at 0° C. and stirred for 15 minutes. The reaction was then warmed to room temperature and stirred for 3 hours. Ammonia was bubbled through the reaction for 30 minutes. Water was then added. The product was filtered off ,and pumped on to provide the title A compound (3.81 g).

1. stirringstirred for 3 hours
2. customAmmonia was bubbled through the reaction for 30 minutes
3. additionWater was then added
4. filtrationThe product was filtered off