Trifluoroacetic acid → HCID 22885700, compound

HRID 1289958Notes

Reaction equation

HRID 1289958 reaction equation
[F:1][C:2]([F:39])([F:38])[C:3]1[CH:4]=[C:5]([C@H:13]([O:15][C@H:16]2[CH2:20][CH2:19][C@@H:18]([N:21]([CH2:23][C:24]([O:26]C(C)(C)C)=[O:25])[CH3:22])[C@@H:17]2[C:31]2[CH:36]=[CH:35][C:34]([F:37])=[CH:33][CH:32]=2)[CH3:14])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.C(O)(C(F)(F)F)=O>C1(OC)C=CC=CC=1>[F:39][C:2]([F:1])([F:38])[C:3]1[CH:4]=[C:5]([C@H:13]([O:15][C@H:16]2[CH2:20][CH2:19][C@@H:18]([N:21]([CH2:23][C:24]([OH:26])=[O:25])[CH3:22])[C@@H:17]2[C:31]2[CH:32]=[CH:33][C:34]([F:37])=[CH:35][CH:36]=2)[CH3:14])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22885705HCID 22885705, compound

Product 1

HCID 22885700HCID 22885700, compound

Reagents, catalysts & solvents 1

HCID 7519AnisoleCatalyst

Procedure

To 280 mg of t-butyl ester from Step A was added 2 drops of anisole and 4 mL of TFA. After 75 min the volatiles were removed in vacuo followed by evaporation of two portions of methylene chloride. The residue was used directly in the Step C.

Workup

  1. customAfter 75 min the volatiles were removed in vacuo
  2. customfollowed by evaporation of two portions of methylene chloride

Sources & evidence

ORD record
ord-917ba84dd21b4653b699c33f9d7604bf
Source dataset
uspto-grants-1998_05
Patent number
US05750549

Reaction notes

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