Hydrochloric Acid → HCID 67669777, compound

HRID 1289997Notes

Reaction equation

HRID 1289997 reaction equation
[CH3:1][O:2][C:3]([CH:5]1[CH2:9][CH2:8][CH:7]([NH:10][CH2:11][C:12]2[CH:17]=[C:16]([C:18]3[C:19]([CH3:24])=[N:20][O:21][C:22]=3[CH3:23])[CH:15]=[CH:14][C:13]=2[O:25][CH3:26])[CH:6]1[C:27]1[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=1)=[O:4].[ClH:34]>CO.C(OCC)C>[ClH:34].[CH3:1][O:2][C:3]([CH:5]1[CH2:9][CH2:8][CH:7]([NH:10][CH2:11][C:12]2[CH:17]=[C:16]([C:18]3[C:19]([CH3:24])=[N:20][O:21][C:22]=3[CH3:23])[CH:15]=[CH:14][C:13]=2[O:25][CH3:26])[CH:6]1[C:27]1[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=1)=[O:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67668612HCID 67668612, compound

Product 1

HCID 67669777HCID 67669777, compound

Reagents, catalysts & solvents 1

HCID 21864698Diethyl ether methanolSolvent

Procedure

Exposure of the product from Step A above to 1.0 equivalent of HCl in methanol/ethyl ether followed by evaporation provided the title compound. NMR (400 MHz, CD3OD): δ 7.43-7.37 (m, 3H), 7.26-7.19 (m, 3H), 7.14 (d, 1H, J=9 Hz), 4.25 (d, 1H, J=13 Hz), 4.10 (d, 1H, J=13 Hz), 3.95-3.85 (m, 2H), 3.74 (s, 3H), 3.63 (s, 3H), 3.37 (quartet, 1H, J=9 Hz), 2.48-2.38 (m, 2H), 2.36 (s, 3H), 2.20 (s, 3H), 2.16-1.96 (m, 2H).

Sources & evidence

ORD record
ord-0b0ae7f006c145729d31562d5c6f15b0
Source dataset
uspto-grants-1998_05
Patent number
US05750549

Reaction notes

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