反应详情

The title compound was prepared by the treatment of 5-bromo-2-isopropoxy-benzaldehyde (3.5 gm, 0.014 mol) with copper(I) cyanide (2.5 gm, 0.028 mol) in refluxing DMF for 28 hours. The cooled mixture was poured into a mixture of water (100 mL) and ethyl acetate (100 mL). The mixture was filtered through a pad of Celite, the organic layer separated, washed with saturated brine solution, dried (Na2SO4), and evaporated. The title compound was purified by flash chromatography eluting with 15% ethyl acetate in hexane; yield 1.9 gm of a white solid.

1. filtrationThe mixture was filtered through a pad of Celite
2. customthe organic layer separated
3. washwashed with saturated brine solution
4. dry with materialdried (Na2SO4)
5. customevaporated
6. customThe title compound was purified by flash chromatography
7. washeluting with 15% ethyl acetate in hexane