Hydrogen Bromide → (R)-3-(3,4-Dihydroxyphenyl)-2-propylamine hydrobromide

HRID 1290068Notes

Reaction equation

HRID 1290068 reaction equation
Cl.C[O:3][C:4]1[CH:5]=[C:6]([CH2:12][C@H:13]([NH2:15])[CH3:14])[CH:7]=[CH:8][C:9]=1[O:10]C.[BrH:16]>>[BrH:16].[OH:3][C:4]1[CH:5]=[C:6]([CH2:12][C@H:13]([NH2:15])[CH3:14])[CH:7]=[CH:8][C:9]=1[OH:10]

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 155566073,4-Dma hydrochloride, (R)-

Product 1

HCID 67643451(R)-3-(3,4-Dihydroxyphenyl)-2-propylamine hydrobromide

Procedure

A solution of (R)-3-(3,4-dimethoxyphenyl)-2-propylamine hydrochloride (500 mg, 2.15 mMol) in hydrogen bromide (48%, 5 ml) was stirred at 100° C. under an argon atmosphere for 20 hours. After cooling, the solvent was evaporated and the residue was dried giving the title compound.

Workup

  1. temperatureAfter cooling
  2. customthe solvent was evaporated
  3. customthe residue was dried

Sources & evidence

ORD record
ord-48f7db6293ca45a6bf7fec2b5b5d0968
Source dataset
uspto-grants-1998_05
Patent number
US05750701

Reaction notes

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