L-Tartaric acid → HCID 178485756, compound

HRID 1290077Notes

Reaction equation

HRID 1290077 reaction equation
[CH:1]1([CH2:7][C@H:8]([NH:19][C:20](=[O:49])[C@H:21]([CH2:43][C:44]2[N:48]=[CH:47][NH:46][CH:45]=2)[N:22]([CH3:42])[C:23](=[O:41])[C@H:24]([CH2:34][C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[NH:25][C:26]([N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[O:27])[C@@H:9]([OH:18])[CH2:10][C@H:11]2[C:15]([CH3:17])([CH3:16])[O:14][CH2:13][O:12]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:50]([OH:59])(=[O:58])[C@@H:51]([C@H:53]([C:55]([OH:57])=[O:56])[OH:54])[OH:52]>C(OCC)(=O)C.C(O)C>[C:55]([C@@H:53]([C@H:51]([C:50]([OH:59])=[O:58])[OH:52])[OH:54])([OH:57])=[O:56].[CH:1]1([CH2:7][C@H:8]([NH:19][C:20](=[O:49])[C@H:21]([CH2:43][C:44]2[N:48]=[CH:47][NH:46][CH:45]=2)[N:22]([CH3:42])[C:23](=[O:41])[C@H:24]([CH2:34][C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=2)[NH:25][C:26]([N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[O:27])[C@@H:9]([OH:18])[CH2:10][C@H:11]2[C:15]([CH3:17])([CH3:16])[O:14][CH2:13][O:12]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 2

HCID 444305L-Tartaric acidHCID 178485751HCID 178485751, compound

Product 1

HCID 178485756HCID 178485756, compoundYield 68.7%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8857Ethyl AcetateSolvent2×

Procedure

The compound (300 mg) obtained in Example 1 was dissolved in ethyl acetate (4.5 ml) and a solution of L-tartaric acid (66 mg) in ethyl acetate (5 ml) and ethanol (0.5 ml) was dropwise added. After stirring overnight at room temperature, crystals were collected by filtration and dried under reduced pressure to give 251 mg of the title compound as white crystals (see Table 16).

Workup

  1. filtrationcrystals were collected by filtration
  2. customdried under reduced pressure

Sources & evidence

ORD record
ord-e6223c0ac8df4c57b301df180c926246
Source dataset
uspto-grants-1998_05
Patent number
US05750696

Reaction notes

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