反应详情

温度

85 °C

57.6 g (0.4 mol) of 2-naphthol and 200 ml of hydrazine (4 mol) are introduced into a 500 ml autoclave. The mixture is stirred at 85° C. at a pressure of 60 bar for approximately 100 hours. The reaction medium is subsequently extracted with dichloromethane. The organic phase is washed with 10% sodium hydroxide, then with water and finally with brine; it is dried over magnesium sulphate. After filtration and evaporation under vacuum, 50.6 g (80%) of product are obtained, the melting point of which is 124° C. (alcohol/water).

1. extractionThe reaction medium is subsequently extracted with dichloromethane
2. washThe organic phase is washed with 10% sodium hydroxide
3. dry with materialit is dried over magnesium sulphate
4. filtrationAfter filtration and evaporation under vacuum, 50.6 g (80%) of product
5. customare obtained
6. customis 124° C.