Dichloromethane → HCID 86752561, compound

HRID 1290395Notes

Reaction equation

HRID 1290395 reaction equation
Cl[C:2]([O:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[CH:8][CH:7]=1)=[O:3].CC[N:17]([CH:21]([CH3:23])C)[CH:18]([CH3:20])C.C(Cl)Cl.[O:27]1C[CH2:30][CH2:29][CH2:28]1.C(OCC)(=[O:34])C.CCCCCC>>[N+:12]([C:9]1[CH:10]=[CH:11][C:6]([CH2:5][O:4][C:2](=[O:3])[N:17]([CH2:18][CH3:20])[CH2:21][C@H:23]2[CH2:30][C@@H:29]([OH:34])[CH2:28][O:27]2)=[CH:7][CH:8]=1)([O-:14])=[O:13]

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 8028TetrahydrofuranHCID 782054-Nitrobenzyl chloroformateHCID 81531DiisopropylethylamineHCID 21226206Ethyl acetate hexane

Product 1

HCID 86752561HCID 86752561, compound

Procedure

The title compound is prepared by the procedure of Example 124 using 4.6 g of product from Example 130, 4.73 g of 4-nitrobenzyl chloroformate, 2.7 ml of Hunig's base, 25 ml of methylene chloride and 7 ml of tetrahydrofuran to give 2.035 g of the desired product after chromatography (silica gel: 75% ethyl acetate/hexane).

Sources & evidence

ORD record
ord-420634bdfce24e34af9b469eec65b910
Source dataset
uspto-grants-1998_05
Patent number
US05750735

Reaction notes

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