Tetrahydrofuran → HCID 12336001, compound

HRID 1290451Notes

Reaction equation

HRID 1290451 reaction equation
[O:1]1[C:5]2([CH2:10][CH2:9][S:8][CH:7]([S:11]C(=O)C)[CH2:6]2)[O:4][CH2:3][CH2:2]1.C[O-].[Na+].O1CCCC1.OP([O-])(O)=O.[K+]>C(OCC)(=O)C>[O:1]1[C:5]2([CH2:10][CH2:9][S:8][CH:7]([SH:11])[CH2:6]2)[O:4][CH2:3][CH2:2]1

Participants

6

Reactant 4

HCID 8028TetrahydrofuranHCID 516951Monobasic potassium phosphateHCID 10942334Sodium MethoxideHCID 53909053HCID 53909053, compound

Product 1

HCID 12336001HCID 12336001, compoundYield 80.5%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 0.56 g of product from Example 395, 0.60 ml of 4.37M sodium methoxide and 10 ml of tetrahydrofuran is stirred in an ice bath for 20 minutes. Ethyl acetate is added followed by 0.5M potassium phosphate monobasic. The organic layer is dried and concentrated in vacuo to give 0.37 g of the desired product as a yellow oil.

Workup

  1. customThe organic layer is dried
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-4fbd503c230c4ec2aa56f032815c6912
Source dataset
uspto-grants-1998_05
Patent number
US05750735

Reaction notes

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