反应详情

Benzil (10 g, 48 mmol) and sulfamide (4.6 g, 48 mmol) were combined in anhydrous, denatured ethanol (100 mL) and dry hydrogen chloride gas was bubbled into the reaction mixture until the temperature reached 55° C. The mixture was heated at reflux for 2 hrs, allowed to equilibrate and proceed overnight at room temperature. Concentration of the mixture gave a light yellow solid which was triturated first with water then with ether yielding 10.74 g (83%) of a white solid. The solids may be recrystallized if necessary from acetone to give white crystals.

1. customwas bubbled into the reaction mixture until the temperature
2. customreached 55° C
3. temperatureThe mixture was heated
4. temperatureat reflux for 2 hrs
5. customConcentration of the mixture gave a light yellow solid which
6. customwas triturated first with water
7. customThe solids may be recrystallized if necessary from acetone
8. customto give white crystals