Methane → Octahydro-6,6-diphosphono-1-(2-mercaptoethyl)-1-methyl-1-pyrindinium chloride

HRID 1290655Notes

Reaction equation

HRID 1290655 reaction equation
[Br-].[P:2]([C:6]1([P:22]([OH:25])([OH:24])=[O:23])[CH2:14][CH:13]2[CH:8]([CH2:9][CH2:10][CH2:11][N+:12]2([CH2:16][CH2:17][S:18]C(=O)C)[CH3:15])[CH2:7]1)([OH:5])([OH:4])=[O:3].C.[ClH:27]>>[Cl-:27].[P:22]([C:6]1([P:2]([OH:5])([OH:4])=[O:3])[CH2:14][CH:13]2[CH:8]([CH2:9][CH2:10][CH2:11][N+:12]2([CH2:16][CH2:17][SH:18])[CH3:15])[CH2:7]1)([OH:24])([OH:25])=[O:23]

Participants

4

Reactant 3

HCID 297MethaneHCID 313Hydrochloric AcidHCID 18916577HCID 18916577, compound

Product 1

HCID 86752569Octahydro-6,6-diphosphono-1-(2-mercaptoethyl)-1-methyl-1-pyrindinium chloride

Procedure

Octahydro-6,6-diphosphono-1-(2-acetylthioethyl)-1-methyl-1-pyrindinium bromide (0.05 mmol) is heated at reflux in 6N HCl (15 ml) under an atmosphere of nitrogen. The reaction mixture is cooled, treated with charcoal and filtered. The resulting filtrate is concentrated under reduced pressure. The resulting solid residue can be recrystallized from water and ethanol to provide the desired product.

Workup

  1. temperatureThe reaction mixture is cooled
  2. filtrationfiltered
  3. concentrationThe resulting filtrate is concentrated under reduced pressure
  4. customThe resulting solid residue can be recrystallized from water and ethanol

Sources & evidence

ORD record
ord-a7c1acfee915465a822acf10115a7627
Source dataset
uspto-grants-1998_05
Patent number
US05753634

Reaction notes

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