反应详情

A mixture of 4-hydroxy-2,3-dimethylbenzaldehyde (220 mg), 4-isobutylbenzyl bromide (341 mg), potassium carbonate (1.38 g) and ethyl methyl ketone (10 ml) was refluxed for 6 hrs. After cooling, the reaction mixture was diluted with ethyl acetate, the solution was washed with dil hydrochloric acid, water, successively, dried and evaporated. The residue was purified by column chromatography on silica gel (hexane:EtOAc=10:1) to give the title compound (383 mg) having the following physical data:

1. temperaturewas refluxed for 6 hrs
2. temperatureAfter cooling
3. washthe solution was washed with dil hydrochloric acid, water
4. customsuccessively, dried
5. customevaporated
6. customThe residue was purified by column chromatography on silica gel (hexane:EtOAc=10:1)