反应详情

To a solution of 2,6-dichloropurine (3.25 g) in DMF (34 ml) was added potassium carbonate (2.85 g) as well as 4-(4-chlorobenzoyl)benzyl bromide (5.32 g) and the mixture was stirred at room temperature for 24 hours. This reaction mixture was diluted with water and extracted with ethyl acetate and the extract was washed with saturated aqueous NaCl solution and dried over anhydrous sodium sulfate. The solvent was then distilled off and the residue was purified by silica gel column chromatography (hexane: ethyl acetate=1:1-1:3) to provide the title compound (1.37 g, 19%) as colorless (anhydrous) powder. 1H-NMR (CDCl3) δ5.76(2H,s), 7.21-7.85(8H,m), 8.33(1H,s).

1. extractionextracted with ethyl acetate
2. washthe extract was washed with saturated aqueous NaCl solution
3. dry with materialdried over anhydrous sodium sulfate
4. distillationThe solvent was then distilled off
5. customthe residue was purified by silica gel column chromatography (hexane: ethyl acetate=1:1-1:3)